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KMID : 0358319960370020169
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Korean Journal of Urology
1996 Volume.37 No. 2 p.169 ~ p.173
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The Effectiveness of Imipramine and Desmopressin in the Treatment of Enuresis
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Abstract
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Nocturnal enuresis is by any standard the most benign voiding dysfunction in children, with a spontaneous cure rate of up to 15% per year. On the other hand it is one of the most sociopsychologically disturbing diseases in children because of its
association with taboos and rites, and for families with bedwetters it is also a significant economic burden. Many investigators have reported upon the effectiveness of drugs in alleviating nocturanl enuresis in children and adults. We evaluated
the
results of drug therapy in 60 children with nocturnal enuresis: 42 boys and 18 girls, mean age 8.7 years(range 5-15). All children were evaluated after treatment with imipramine, and the response rate of imipramine was 76.7%. For the remaining 14
non-responders, desmopressin was given intranasally at bedtime. And the response rate of desmoopressin was 64.3%. So, the overall response rate of inmijpramine and desmopressin was 91.7%. No serious side effects were observed.
These data show that the combined therapy with imipramine and desmopressin is very effective in treating enuresis.
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